発表論文

1. Mohammed T.A. Salim, Hiroshi Aoyama, Kazuyuki Sugita, Kouichi Watashi, Takaji Wakita, Takayuki Hamasaki, Mika Okamoto, Yasuo Urata, Yuichi Hashimoto, Masanori Baba: Potent and selective inhibition of hepatitis C virus replication by novel phenanthridinone derivatives, Biochem. Biophys. Res. Commun., 415, 714-719 (2011).

2. Ichikawa, Masanori; Yokomizo, Aki; Itoh, Masao; Haginoya, Noriyasu; Kazuyuki Sugita; Usui, Hiroyuki; Terayama, Koji; Kanda, Akira: Discovery of atrop fixed alkoxy-aminobenzhydrol derivatives: Novel, highly potent and orally efficacious squalene synthase inhibitors, Bioorg. Med. Chem., 19(17), 5207-5224 (2011).

3. Tomomi Noguchi-Yachide, Kazuyuki Sugita and Yuichi Hashimoto: Estrogen receptor α/β ligands derived from thalidomide, Heterocycles, 83(9), 2137-2147 (2011).

4. Kazunori Motoshima, Minoru Ishikawa, Yuichi Hashimoto, and Kazuyuki Sugita: Inhibition of restriction enzymes EcoRI and, BamHI and HindIII by phenetylphenyl phthalimides Derived from thalidomide, Chem. Pharm. Bull., 59(7), 880-884 (2011).

5. Kazunori Motoshima, Minoru Ishikawa, Yuichi Hashimoto, Kazuyuki Sugita: Peroxisome proliferator-activated receptor agonists with phenethylphenylphthalimide skeleton derived from thalidomide-related liver X receptor antagonists: Relationship between absolute configuration and subtype selectivity, Bioorg. Med. Chem., 19(10), 3156-3172 (2011).

6. Kazunori Motoshima, Kazuyuki Sugita, Yuichi Hashimoto, Minoru Ishikawa: Non-competitive and selective dipeptidyl peptidase IV inhibitors with phenethylphenylphthalimide skeleton derived from thalidomide-related α-glucosidase inhibitors and liver X receptor antagonists, Bioorg. Med. Chem. Lett., 21(10), 3041-3045 (2011).

7. Hiroshi Aoyama, Kazuyuki Sugita, Masahiko Nakamura, Atsushi Aoyama, Mohammed T. Salim, Mika Okamoto, Masanori Baba, Yuichi Hashimoto: Fused heterocyclic amido compounds as anti-hepatitis C virus agents, Bioorg. Med. Chem., 19(8), 2675-2687 (2011).

8. Kazunori Motoshima, Tomomi Noguchi-Yachide, Minoru Ishikawa, Yuichi Hashimoto, Kazuyuki Sugita: Further application of the multi-template approach for creation of biological response modifiers: discovery of a new class of multifunctional anti-diabetic agents, Heterocycles, 82(2), 1083-1101 (2011).

9. Masanori Ichikawa, Aki Yokomizo, Masao Itoh, Kazuyuki Sugita, Hiroyuki Usui, Hironari Shimizu, Makoto Suzuki, Koji Terayama, Akira Kanda: Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors, Bioorg. Med. Chem., 19(6), 1930-1949 (2011).

10. W. Chen, K. Kobayashi, K. Takahashi, and T. Honda: Synthetic approach to 4α-methyltetrahydrofluorene-type diterpenoids via an aromatic oxidation of phenol derivatives, Synth. Commun., 41, 3385-3402 (2011).

11. H. Kasai, N. Saito, and T. Honda: Structural features of polyacylated anthocyanins using matrix-assisted laser desorption/ionization and electrospray ionization time-of-flight mass spectrometry, Rapid Comm. Mass Spectrom., 25, 1051-1060 (2011).

12. T. Honda, T. Matsukawa, and K. Takahashi: Efficient total synthesis of (-)-stemoamide, Org. Biomol. Chem., 9, 673-675 (2011).

13. F. Tatsuzawa, K. Miyoshi, T. Yukawa, K. Shinoda, K. Toki, N. Saito, A. Shigihara, and T. Honda: Malonylated anthocyanidin 3,5-diglucosides in the flowers of the genus Disa (Orchidaceae), Biochem. Syst. Ecol., 39, 220-224 (2011).

14. N. Saito, F. Tatsuzawa, K. Toki, K. Shinoda, A. Shigihara and T. Honda: The blue anthocyanin pigments from the blue flowers of Heliophila coronopifolia L. (Cruciferae), Phytochemistry, 72, 2219-2229 (2011). (IF : 3.35)

15. N. Saito, F. Tatsuzawa, A. Hoshino, Y. Abe, M. Ichimura, M. Yokoi, K. Toki, Y. Morita, S. Iida, and T. Honda: Anthocyanin pigmentation controlled by speckled and c-1 mutations of Japanese morning glory, J. Japan. Soc. Hort. Sci., 80, 452-460 (2011).

16. K. Toki, N. Saito, F. Tatsuzawa, A. Shigihara, and T. Honda: 7-O-Methylated anthocyanidin glycosides from the reddish purple flowers of Catharanthus roseus 'Equator Lavender', Heterocycles, 83, 2803-2810 (2011).

17. J. Deguchi, T. Hirahara, S. Oshimi, Y. Hirasawa, W. Ekasari, O. Shirota, T. Honda, and H. Morita: Total synthesis of a novel tetracyclic alkaloid, cassiarin F from the flowers of Cassia siamea, Org. Lett., 13, 4344-4347 (2011). (IF : 5.86)

18. Y. Ito, K. Takahashi, H. Nagase, and T. Honda: Integral stereocontrolled synthesis of a spiro-norlignan, sequosempervirin A: Revision of absolute configuration, Org. Lett., 13, 4640-4643 (2011). (IF : 5.86)

19. M. Inden, Y. Kitamura, K. Takahashi, K. Takata, N. Ito, R. Niwa, R. Funayama, N. Nishimura, T. Taniguchi, T. Honda, T. Taira and H. Ariga: Protection against dopaminergic neurodegeneration in Parkinson's disease-model animals by a modulator of the oxidized form of DJ-1, a wild-type of familial Parkinson's disease-linked PARK7, J. Pharmacol. Sci., 117, 189-203 (2011).

20. T. Honda: Development of samarium diiodide-promoted regioselective carbon-nitrogen bond cleavage reaction of -amino carbonyl compounds: Application to the synthesis of biologically active alkaloids, Heterocycles, 82, 1-46 (2011).

21. Yamamoto, N.; Fujii, H.; Nemoto, T.; Nakajima, R.; Momen, S.; Izumimoto, N.; Hasebe, K.; Mochizuki, H.; Nagase, H.; Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology: Part 1., Bioorg. Med. Chem. Lett., 21, 4104-4107 (2011).

22. Yamamoto, N.; Fujii, H.; Imaide, S.; Hirayama, S.; Nemoto, T.; Inokoshi, J.; Tomoda, H.; Nagase, H.: Synthesis of (-)-homogalanthamine from naltrexone., J. Org. Chem., 76, 2257-2260 (2011). (IF : 4.45)

23. Nemoto, T.; Yamamoto, N.; Watanabe, A.; Fujii, H.; Hasebe, K.; Nakajima, M.; Mochizuki, H.; Nagase, H.; Synthesis of 6,14-epoxymorphinan derivatives and their pharmacologies., Bioorg. Med. Chem., 19, 1205-1221 (2011).

24. Keisuke Maruyama, Tomomi Noguchi-Yachide, Kazuyuki Sugita, Yuichi Hashimoto, Minoru Ishikawa: Novel selective anti-androgens with a diphenylpentane skeleton, Bioorg. Med. Chem. Lett., 20(22), 6661-6666 (2010).

25. Tuma Iwai, Hitoshi Takahashi, Dai Hatakeyama, Kazunori Motoshima, Minoru Ishikawa, Kazuyuki Sugita, Yuichi Hashimoto, Yuichi Harada, Shigeru Itamura, Takao Odagiri, Masato Tashiro, Yoshihisa Sei, Kentaro Yamaguchi, Takashi Kuzuhara: Anti-influenza activity of phenethylphenylphthalimide analogs derived from thalidomide, Bioorg. Med. Chem., 18(14), 5379-5390 (2010).

26. Takashi Misawa, Mokammed T. A. Salim, Mika Okamoto, Masanori Baba, Hiroshi Aoyama, Yuichi Hashimoto, Kazuyuki Sugita: Synthesis and anti-hepatitis C virus activity of morpholino triazine derivatives, Heterocycles, 81(6), 1419-1426 (2010).

27. T. Honda and C. Hisa: Application of samarium-diiodide promoted reductive carbon-nitrogen bond cleavage reaction to 3-oxopyrrolidine derivatives: Alternative synthesis of a coccinellid alkaloid, (+)-adalinine, Heterocycles, 80, 1381-1406 (2010).

28. F. Tatsuzawa, N. Saito, R. Usuki, K. Toki, K. Shinoda, A. Shigihara, and T. Honda: Acylated pelargonidin 3-sambubioside-5-glucosides from the red-purple flowers of Lobularia maritima, J. Japan. Soc. Hort. Sci., 79, 84-90 (2010).

29. F. Tatsuzawa, N. Saito, K. Toki, K. Shinoda, A. Shigihara, and T. Honda: Acylated cyanidin 3-sophoroside-5-glucosides from the purple roots of red radish (Raphanus sativus L.) 'Benikanmi', J. Japan. Soc. Hort. Sci., 79, 103-107 (2010).

30. T. Matsumoto, T. Kobayashi, K. Ishida, Y. Hirasawa, H. Morita, T. Honda and K. Kamata: Vasodilator effect of cassiarin A, a novel antiplasmodial alkaloid from Cassia siamea, in rat isolated mesenteric artery, Biol. Pharm. Bull., 33, 844-848 (2010).

31. F. Tatsuzawa, N. Saito, A. Shigihara, T. Honda, K. Toki, K. Shinoda, T. Yukawa, and K. Miyoshi An acylated cyanidin 3,7-diglucoside in the bluish flowers of Bletilla striata 'Murasaki Shikibu' (Orchidaceae), J. Japan. Soc. Hort. Sci., 79, 215-220 (2010).

32. K. Takahashi, K. Takeda and T. Honda: Efficient formal synthesis of (±)-axamide-1 and (±)-axisonitrile-1 via an intramolecular Hosomi-Sakurai reaction, Tetrahedron Lett., 51, 3542-3544 (2010).

33. K. Takahashi and T. Honda: Diastereoselective syntheses of functionalized five-membered carbocycles and heterocycles by a SmI2-promoted intramolecular coupling of bromoalkynes and α,β-unsaturated esters, Org. Lett., 12, 3026-3029 (2010). (IF : 5.86)

34. T. Honda: Development of an efficient synthetic strategy for bioactive alkaloids possessing a spirocyclic ring system, Pure & Applied Chemistry, 82, 1773-1783 (2010).

35. F. Tatsuzawa, N. Saito, K. Maeyama, M. Yokoi, A. Shigihara, and T. Honda: Triacylated anthocyanidin 3-arabinosylglucoside-7,3'-diglucosides isolated from the bluish flowers of Tradescantia virginiana cultivars and their distribution in the Tradescantieae, Heterocycles, 81, 2257-2267 (2010).

36. K. Taguchi, K. Kobayashi, K. Ishida, K. Kamata, and T. Honda: Synthesis and evaluation of phosphodiesterase IV inhibitory potency of isocarbostyril derivatives of naturally occurring isocoumarins, scoparines A and B, Heterocycles, 81, 2635-2647 (2010).

37. M. Tsubuki, T. Abekura, K. Takahashi, and T. Honda: Enantioselective synthesis of the C(2)-C(11) cyclopropylfuran segment of pinnatin A, Heterocycles, 82, 319-323 (2010).

38. Nagase, H.; Nemoto, T.; Matsubara, A.; Saito, M.; Yamamoto, N.; Osa, Y.; Hirayama, S.; Nakajima, M.; Nakao, K.; Mochizuki, H.; Fujii, H.: Design and synthesis of KNT-127, a δ-opioid receptor agonist effective by systemic administration., Bioorg. Med. Chem. Lett., 20, 6302-6305 (2010).

特許

1. Baba, Masanori; Hashimoto, Yuichi; Aoyama, Hiroshi; Sugita, Kazuyuki; Nakamura, Masahiko; Aoyama, Atsushi; Urata, Yasuo: Preparation of phenanthridin-6(5H)-one compounds as therapeutic agents for hepatitis C, PCT Int. Appl. (2011), 120pp. WO 2011093483 A1 20110804.

2. Nakayama, Kiyoshi; Sugita, Kazuyuki; Setoguchi, Masaki; Tominaga, Yuichi; Saito, Masaki; Odagiri, Takashi: Preparation of morpholinopurine compounds for inhibiting PI3K and/or mTOR, Jpn. Kokai Tokkyo Koho (2011), 225pp. JP 2011236198 A 20111124.

3. Nakayama, Kiyoshi; Sugita, Kazuyuki; Setoguchi, Masaki; Tominaga, Yuichi; Saitou, Masanori; Odagiri, Takashi: Preparation of morpholinopurine compounds as PI3K and/or mTOR inhibitors, PCT Int. Appl. (2010), 335pp. WO2010044401 A1 20100422.

4. Sugita, Kazuyuki; Otsuka, Masaki; Oki, Hitoshi; Haginoya, Noriyasu; Ichikawa, Masanori; Ota, Masahiro; Shibata, Norihiro: Preparation of tricyclic heteroaryl compounds as squalene synthase inhibitors, Jpn. Kokai Tokkyo Koho (2010), 277pp. JP2010150142 A 20100708.

5. Sugita, Kazuyuki; Ito, Masao; Ichikawa, Masanori: Preparation of tricyclic aryl compounds as squalene synthase inhibitors, Jpn. Kokai Tokkyo Koho (2010), 116pp. JP2010120929 A 20100603.

6. Sugita, Kazuyuki; Otsuka, Masaki; Oki, Hitoshi; Haginoya, Noriyasu; Ichikawa, Masanori; Ota, Masahiro; Shibata, Norihiro: Preparation of tricyclic heteroaryl compounds as squalene synthase inhibitors, Jpn. Kokai Tokkyo Koho (2010), 154pp. JP2010100566 A 20100506.

7. Sugita, Kazuyuki; Haginoya, noriyasu: Preparation of substituted tricyclic heteroaryl compound as squalene and cholesterol synthetase inhibitors, PCT Int. Appl. (2010), 139pp. WO2010041726 A1 20100415.

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