星薬科大学生化学

セミナーについて(通常分)

バーチャルセミナーの記録(2020年春学期)

文献紹介

本研究室での研究につながりのある論文がセミナーで紹介されました。研究や文献紹介の参考にしてください。
3年生は2名で分担して、4年生以上では論文全体を紹介できるように頑張りましょう。

●2020年春学期(バーチャルセミナー)

Interferon-induced transmembrane proteins inhibit cell fusion mediated by trophoblast syncytins. Zani A, Zhang L, McMichael TM, Kenney AD, Chemudupati M, Kwiek JJ, Liu SL, Yount JS. J Biol Chem. 2019 Dec 27;294(52):19844-19851. doi: 10.1074/jbc.AC119.010611. PMID: 31735710 by YI, RK, NS

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, Schiergens TS, Herrler G, Wu NH, Nitsche A, Müller MA, Drosten C, Pöhlmann S. Cell. 2020 Apr 16;181(2):271-280.e8. doi: 10.1016/j.cell.2020.02.052. Epub 2020 Mar 5. PMID: 32142651 by YT, MT, RN

Heparanase activates the syndecan-syntenin-ALIX exosome pathway. Roucourt B, Meeussen S, Bao J, Zimmermann P, David G. Cell Res. 2015 Apr;25(4):412-28. doi: 10.1038/cr.2015.29. Epub 2015 Mar 3. PMID: 25732677 by MH, RB, MY

Epithelial Heparan Sulfate Contributes to Alveolar Barrier Function and Is Shed during Lung Injury. Haeger SM, Liu X, Han X, McNeil JB, Oshima K, McMurtry SA, Yang Y, Ouyang Y, Zhang F, Nozik-Grayck E, Zemans RL, Tuder RM, Bastarache JA, Linhardt RJ, Schmidt EP. Am J Respir Cell Mol Biol. 2018 Sep;59(3):363-374. doi: 10.1165/rcmb.2017-0428OC. PMID: 29584451 by YY, HY, KW

Saponin 1 induces apoptosis and suppresses NF-κB-mediated survival signaling in glioblastoma multiforme (GBM). Li J, Tang H, Zhang Y, Tang C, Li B, Wang Y, Gao Z, Luo P, Yin A, Wang X, Cheng G, Fei Z. PLoS One. 2013 Nov 21;8(11):e81258. doi: 10.1371/journal.pone.0081258. eCollection 2013. PMID: 24278406 by SI

Induction of Human Lung Mast Cell Apoptosis by Granule Permeabilization: A Novel Approach for Targeting Mast Cells. Paivandy A, Sandelin M, Igelström H, Landelius P, Janson C, Melo FR, Pejler G. Front Immunol. 2017 Nov 27;8:1645. doi: 10.3389/fimmu.2017.01645. eCollection 2017. PMID: 29230220 by FI

Water Extract of Curcuma longa L. Ameliorates Non-Alcoholic Fatty LiverDisease. Mun J, Kim S, Yoon HG, You Y, Kim OK, Choi KC, Lee YH, Lee J, Park J, Jun W. Nutrients. 2019 Oct 21;11(10):2536. doi: 10.3390/nu11102536. PMID: 31640183 by YU

EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration. Aiello NM, Maddipati R, Norgard RJ, Balli D, Li J, Yuan S, Yamazoe T, Black T, Sahmoud A, Furth EE, Bar-Sagi D, Stanger BZ. Dev Cell. 2018 Jun 18;45(6):681-695.e4. doi: 10.1016/j.devcel.2018.05.027. PMID: 29920274 by TU

Bergamot Polyphenols Improve Dyslipidemia and Pathophysiological Features in a Mouse Model of Non-Alcoholic Fatty Liver Disease. Musolino V, Gliozzi M, Scarano F, Bosco F, Scicchitano M, Nucera S, Carresi C, Ruga S, Zito MC, Maiuolo J, Macrì R, Amodio N, Juli G, Tassone P, Mollace R, Caffrey R, Marioneaux J, Walker R, Ehrlich J, Palma E, Muscoli C, Bedossa P, Salvemini D, Mollace V, Sanyal AJ. Sci Rep. 2020 Feb 13;10(1):2565. doi: 10.1038/s41598-020-59485-3. PMID: 32054943 by SK

Heparanase-2 protects from LPS-mediated endothelial injury by inhibiting TLR4 signalling. Kiyan Y, Tkachuk S, Kurselis K, Shushakova N, Stahl K, Dawodu D, Kiyan R, Chichkov B, Haller H. Sci Rep. 2019 Sep 19;9(1):13591. doi: 10.1038/s41598-019-50068-5. PMID: 31537875 by DK

●2019年秋学期

Soluble heparan sulfate fragments generated by heparanase trigger the release of pro-inflammatory cytokines through TLR-4. Goodall KJ, Poon IK, Phipps S, Hulett MD. PLoS One. 2014 Oct 8;9(10):e109596. doi: 10.1371/journal.pone.0109596. PMID: 25295599 by JS

Heparanase plays a dual role in driving hepatocyte growth factor (HGF) signaling by enhancing HGF expression and activity. Ramani VC, Yang Y, Ren Y, Nan L, Sanderson RD. J Biol Chem. 2011 Feb 25;286(8):6490-9. doi: 10.1074/jbc.M110.183277. Epub 2010 Dec 3. PMID: 21131364 by XX

Three Dimensional Mixed-Cell Spheroids Mimic Stroma-Mediated Chemoresistance and Invasive Migration in hepatocellular carcinoma. Khawar IA, Park JK, Jung ES, Lee MA, Chang S, Kuh HJ. Neoplasia. 2018 Aug;20(8):800-812. doi: 10.1016/j.neo.2018.05.008. Epub 2018 Jul 4. PMID: 29981501 by RK

Matrix metalloproteinase-9 deficiency protects mice from severe influenza A viral infection. Rojas-Quintero J, Wang X, Tipper J, Burkett PR, Zuñiga J, Ashtekar AR, Polverino F, Rout A, Yambayev I, Hernández C, Jimenez L, Ramírez G, Harrod KS, Owen CA. JCI Insight. 2018 Dec 20;3(24). pii: 99022. doi: 10.1172/jci.insight.99022. PMID: 30568032 by MW

Suppressyn localization and dynamic expression patterns in primary human tissues support a physiologic role in human placentation. Sugimoto J, Schust DJ, Kinjo T, Aoki Y, Jinno Y, Kudo Y. Sci Rep. 2019 Dec 20;9(1):19502. doi: 10.1038/s41598-019-55933-x. PMID: 31862915 by MY

IL-8 promotes cell migration through regulating EMT by activating the Wnt/β-catenin pathway in ovarian cancer. Wen J, Zhao Z, Huang L, Wang L, Miao Y, Wu J. J Cell Mol Med. 2020 Jan;24(2):1588-1598. doi: 10.1111/jcmm.14848. Epub 2019 Dec 2. PMID: 31793192 by SF

NFκB activation in differentiating glioblastoma stem-like cells is promoted by hyaluronic acid signaling through TLR4. Ferrandez E, Gutierrez O, Segundo DS, Fernandez-Luna JL. Sci Rep. 2018 Apr 20;8(1):6341. doi: 10.1038/s41598-018-24444-6. PMID: 29679017 by SF

Hyaluronidase-4 is produced by mast cells and can cleave serglycin chondroitin sulfate chains into lower molecular weight forms. Farrugia BL, Mizumoto S, Lord MS, O'Grady RL, Kuchel RP, Yamada S, Whitelock JM. J Biol Chem. 2019 Jul 26;294(30):11458-11472. doi: 10.1074/jbc.RA119.008647. Epub 2019 Jun 7. PMID: 31175155 by HT

Oversulfated chondroitin sulfate binds to chemokines and inhibits stromal cell-derived factor-1 mediated signaling in activated T cells. Zhou ZH, Karnaukhova E, Rajabi M, Reeder K, Chen T, Dhawan S, Kozlowski S. PLoS One. 2014 Apr 9;9(4):e94402. doi: 10.1371/journal.pone.0094402. eCollection 2014. PMID: 24718687 by YT

●2019年春学期

Yin-Yang of IL-33 in Human Skin Mast Cells: Reduced Degranulation, but Augmented Histamine Synthesis through p38 Activation. Babina M, Wang Z, Franke K, Guhl S, Artuc M, Zuberbier T. J Invest Dermatol. 2019 Jan 23. pii: S0022-202X(19)30033-8. doi: 10.1016/j.jid.2019.01.013. [Epub ahead of print] PMID: 30684550 by FI and HT

HSulf-1 deficiency dictates a metabolic reprograming of glycolysis and TCA cycle in ovarian cancer. Mondal S, Roy D, Camacho-Pereira J, Khurana A, Chini E, Yang L, Baddour J, Stilles K, Padmabandu S, Leung S, Kalloger S, Gilks B, Lowe V, Dierks T, Hammond E, Dredge K, Nagrath D, Shridhar V. Oncotarget. 2015 Oct 20;6(32):33705-19. PMID: 26378042 by SF and MW

Lonicera caerulea Extract Attenuates Non-Alcoholic Fatty Liver Disease in Free Fatty Acid-Induced HepG2 Hepatocytes and in High Fat Diet-Fed Mice. Park M, Yoo JH, Lee YS, Lee HJ. Nutrients. 2019 Feb 26;11(3). PMID: 30813654 by SI

PLIN2 Is Essential for Trophoblastic Lipid Droplet Accumulation and Cell Survival During Hypoxia. Bildirici I, Schaiff WT, Chen B, Morizane M, Oh SY, O'Brien M, Sonnenberg-Hirche C, Chu T, Barak Y, Nelson DM, Sadovsky Y. Endocrinology. 2018 Dec 1;159(12):3937-3949. PMID: 30351430 by MY supported by KT

Stepwise inhibition of T cell recruitment at post-capillary venules by orally active desulfated heparins in inflammatory arthritis. Al Faruque H, Kang JH, Hwang SR, Sung S, Alam MM, Sa KH, Nam EJ, Byun RY, Kang YM. PLoS One. 2017 Apr 18;12(4):e0176110. PMID: 28419144 by SI and YT

What Do We Learn from Spheroid Culture Systems? Insights from Tumorspheres Derived from Primary Colon Cancer Tissue. Qureshi-Baig K, Ullmann P, Rodriguez F, Frasquilho S, Nazarov PV, Haan S, Letellier E. PLoS One. 2016 Jan 8;11(1):e0146052. PMID: 26745821 by TU and RK

Heparanase Enhances Tumor Growth and Chemoresistance by Promoting Autophagy. Shteingauz A, Boyango I, Naroditsky I, Hammond E, Gruber M, Doweck I, Ilan N, Vlodavsky I. Cancer Res. 2015 Sep 15;75(18):3946-57. PMID: 26249176 by DK and SF

●2018年秋学期

Heparanase regulates esophageal keratinocyte differentiation through nuclear translocation and heparan sulfate cleavage. Kobayashi M, Naomoto Y, Nobuhisa T, Okawa T, Takaoka M, Shirakawa Y, Yamatsuji T, Matsuoka J, Mizushima T, Matsuura H, Nakajima M, Nakagawa H, Rustgi A, Tanaka N. Differentiation. 2006 Jun;74(5):235-43. PMID: 16759289 by SI

Oral arginine supplementation protects female mice from the onset of non-alcoholic steatohepatitis. Sellmann C, Degen C, Jin CJ, Nier A, Engstler AJ, Hasan Alkhatib D, De Bandt JP, Bergheim I. Amino Acids. 2017 Jul;49(7):1215-1225. PMID: 28434046 by KI

Anti-obesity potential of enzymatic fragments of hyaluronan on high-fat diet-induced obesity in C57BL/6 mice. Park BG, Park YS, Park JW, Shin E, Shin WS. Biochem Biophys Res Commun. 2016 Apr 22;473(1):290-295. PMID: 27012203 by SO

Macrophages induce "budding" in aggressive human colon cancer subtypes by protease-mediated disruption of tight junctions. Trumpi K, Frenkel N, Peters T, Korthagen NM, Jongen JMJ, Raats D, van Grevenstein H, Backes Y, Moons LM, Lacle MM, Koster J, Zwijnenburg D, Borel Rinkes IHM, Kranenburg O. Oncotarget. 2018 Apr 13;9(28):19490-19507. doi: 10.18632/oncotarget.24626. eCollection 2018 Apr 13. PMID: 29731961 by RO

Increased expression of cell adhesion molecule 1 by mast cells as a cause of enhanced nerve-mast cell interaction in a hapten-induced mouse model of atopic dermatitis. Hagiyama M, Inoue T, Furuno T, Iino T, Itami S, Nakanishi M, Asada H, Hosokawa Y, Ito A. Br J Dermatol. 2013 Apr;168(4):771-8. doi: 10.1111/bjd.12108. PMID: 23106683 by FK

VEGF-C expression attributes the risk for lymphatic metastases to ovarian cancer patients. Kuerti S, Oliveira-Ferrer L, Milde-Langosch K, Schmalfeldt B, Legler K, Woelber L, Prieske K, Mahner S, Trillsch F. Oncotarget. 2017 Jun 27;8(26):43218-43227. doi: 10.18632/oncotarget.17978. PMID: 28591727 by AS

Expression of Concentrative Nucleoside Transporters (SLC28A) in the Human Placenta: Effects of Gestation Age and Prototype Differentiation-Affecting Agents. Jiraskova L, Cerveny L, Karbanova S, Ptackova Z, Staud F. Mol Pharm. 2018 Jul 2;15(7):2732-2741. doi: 10.1021/acs.molpharmaceut.8b00238. Epub 2018 May 25. PMID: 29782174 by HT

Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesin. Ashkenazi A, Marsters SA, Capon DJ, Chamow SM, Figari IS, Pennica D, Goeddel DV, Palladino MA, Smith DH. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10535-9. PMID: 1660140 by MH

Chemical or genetic Pin1 inhibition exerts potent anticancer activity against hepatocellular carcinoma by blocking multiple cancer-driving pathways. Liao XH, Zhang AL, Zheng M, Li MQ, Chen CP, Xu H, Chu QS, Yang D, Lu W, Tsai TF, Liu H, Zhou XZ, Lu KP. Sci Rep. 2017 Mar 6;7:43639. doi: 10.1038/srep43639. PMID: 28262728 by JF

Chondroitin sulfate-E mediates estrogen-induced osteoanabolism. Koike T, Mikami T, Shida M, Habuchi O, Kitagawa H. Sci Rep. 2015 Mar 11;5:8994. doi: 10.1038/srep08994. PMID: 25759206 by RM

A small molecule inhibits virion attachment to heparan sulfate- or sialic acid-containing glycans. Colpitts CC, Schang LM. J Virol. 2014 Jul;88(14):7806-17. doi: 10.1128/JVI.00896-14. Epub 2014 Apr 30. PMID: 24789779 by TM

Topical skin treatment with Fab fragments of an allergen-specific IgG1 monoclonal antibody suppresses allergen-induced atopic dermatitis-like skin lesions in mice. Sae-Wong C, Mizutani N, Kangsanant S, Yoshino S. Eur J Pharmacol. 2016 May 15;779:131-7. doi: 10.1016/j.ejphar.2016.03.020. Epub 2016 Mar 9. PMID: 26970183 by NM

●2018年春学期

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway. Chantranupong L, Scaria SM, Saxton RA, Gygi MP, Shen K, Wyant GA, Wang T, Harper JW, Gygi SP, Sabatini DM. Cell. 2016 Mar 24;165(1):153-164. doi: 10.1016/j.cell.2016.02.035. Epub 2016 Mar 10. PMID: 26972053 by YI

mTORC2 Responds to Glutamine Catabolite Levels to Modulate the Hexosamine Biosynthesis Enzyme GFAT1. Moloughney JG, Kim PK, Vega-Cotto NM, Wu CC, Zhang S, Adlam M, Lynch T, Chou PC, Rabinowitz JD, Werlen G, Jacinto E. Mol Cell. 2016 Sep 1;63(5):811-26. doi: 10.1016/j.molcel.2016.07.015. Epub 2016 Aug 25. PMID: 27570073 by SF

Heparanase is preferentially expressed in human psoriatic lesions and induces development of psoriasiform skin inflammation in mice. Lerner I, Zcharia E, Neuman T, Hermano E, Rubinstein AM, Vlodavsky I, Elkin M. Cell Mol Life Sci. 2014 Jun;71(12):2347-2357. doi: 10.1007/s00018-013-1496-9. Epub 2013 Oct 30. PMID: 24169805 by MI

Heparanase is a host enzyme required for herpes simplex virus-1 release from cells. Hadigal SR, Agelidis AM, Karasneh GA, Antoine TE, Yakoub AM, Ramani VC, Djalilian AR, Sanderson RD, Shukla D. Nat Commun. 2015 Apr 27;6:6985. doi: 10.1038/ncomms7985. PMID: 25912399 by MU

Efficient sorting of TNF-alpha to rodent mast cell granules is dependent on N-linked glycosylation. Olszewski MB, Trzaska D, Knol EF, Adamczewska V, Dastych J. Eur J Immunol. 2006 Apr;36(4):997-1008. PMID: 16541468 by YS

Involvement of heparanase in the pathogenesis of acute kidney injury: nephroprotective effect of PG545. Abassi Z, Hamoud S, Hassan A, Khamaysi I, Nativ O, Heyman SN, Muhammad RS, Ilan N, Singh P, Hammond E, Zaza G, Lupo A, Onisto M, Bellin G, Masola V, Vlodavsky I, Gambaro G. Oncotarget. 2017 May 23;8(21):34191-34204. doi: 10.18632/oncotarget.16573. PMID: 28388547 by NS

Epigallocatechin-3-gallate inhibits adipogenesis through down-regulation of PPARγ and FAS expression mediated by PI3K-AKT signaling in 3T3-L1 cells. Wu M, Liu D, Zeng R, Xian T, Lu Y, Zeng G, Sun Z, Huang B, Huang Q. Eur J Pharmacol. 2017 Jan 15;795:134-142. doi: 10.1016/j.ejphar.2016.12.006. Epub 2016 Dec 7. PMID: 27940057 by SS

Pin1-mediated Modification Prolongs the Nuclear Retention of β-Catenin in Wnt3a-induced Osteoblast Differentiation. Shin HR, Islam R, Yoon WJ, Lee T, Cho YD, Bae HS, Kim BS, Woo KM, Baek JH, Ryoo HM. J Biol Chem. 2016 Mar 11;291(11):5555-65. doi: 10.1074/jbc.M115.698563. Epub 2016 Jan 6. PMID: 26740630 by MN

Syndecan-1 Attenuates Lung Injury during Influenza Infection by Potentiating c-Met Signaling to Suppress Epithelial Apoptosis. Brauer R, Ge L, Schlesinger SY, Birkland TP, Huang Y, Parimon T, Lee V, McKinney BL, McGuire JK, Parks WC, Chen P. Am J Respir Crit Care Med. 2016 Aug 1;194(3):333-44. doi: 10.1164/rccm.201509-1878OC. PMID: 26959387 by FA

Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters. Cheung KJ, Padmanaban V, Silvestri V, Schipper K, Cohen JD, Fairchild AN, Gorin MA, Verdone JE, Pienta KJ, Bader JS, Ewald AJ. Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E854-63. doi: 10.1073/pnas.1508541113. Epub 2016 Feb 1. PMID: 26831077 by AK

TNF trafficking to human mast cell granules: mature chain-dependent endocytosis. Olszewski MB, Groot AJ, Dastych J, Knol EF. J Immunol. 2007 May 1;178(9):5701-9. PMID: 17442953 by SS

Tumor suppressor p53 regulates heparanase gene expression. Baraz L, Haupt Y, Elkin M, Peretz T, Vlodavsky I. Oncogene. 2006 Jun 29;25(28):3939-47. Epub 2006 Feb 13. PMID: 16474844 by SS

Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity. Levy-Adam F, Feld S, Cohen-Kaplan V, Shteingauz A, Gross M, Arvatz G, Naroditsky I, Ilan N, Doweck I, Vlodavsky I. J Biol Chem. 2010 Sep 3;285(36):28010-9. doi: 10.1074/jbc.M110.116384. Epub 2010 Jun 24. PMID: 20576607 by AF

Novel Intraperitoneal Treatment With Non-Thermal Plasma-Activated Medium Inhibits Metastatic Potential of Ovarian Cancer Cells. Nakamura K, Peng Y, Utsumi F, Tanaka H, Mizuno M, Toyokuni S, Hori M, Kikkawa F, Kajiyama H. Sci Rep. 2017 Jul 20;7(1):6085. doi: 10.1038/s41598-017-05620-6. PMID: 28729634 by RY

Expression of hypoxia-inducible factor-1 by trophectoderm cells in response to hypoxia and epidermal growth factor. Jeong W, Bazer FW, Song G, Kim J. Biochem Biophys Res Commun. 2016 Jan 8;469(2):176-82. doi: 10.1016/j.bbrc.2015.11.091. Epub 2015 Nov 24. PMID: 26620226 by YY

GATA3 interacts with and stabilizes HIF-1α to enhance cancer cell invasiveness. Lin MC, Lin JJ, Hsu CL, Juan HF, Lou PJ, Huang MC. Oncogene. 2017 Jul 27;36(30):4243-4252. doi: 10.1038/onc.2017.8. Epub 2017 Mar 6. Erratum in: Oncogene. 2017 Jun 12;:. PMID: 28263977 by SI KI HT

Heparanase Mediates Intestinal Inflammation and Injury in a Mouse Model of Sepsis. Chen S, He Y, Hu Z, Lu S, Yin X, Ma X, Lv C, Jin G. J Histochem Cytochem. 2017 Apr;65(4):241-249. doi: 10.1369/0022155417692536. Epub 2017 Feb 7. PMID: 28170292 by SO AS MH

Peptidyl Prolyl Isomerase PIN1 Directly Binds to and Stabilizes Hypoxia-Inducible Factor-1α. Han HJ, Kwon N, Choi MA, Jung KO, Piao JY, Ngo HK, Kim SJ, Kim DH, Chung JK, Cha YN, Youn H, Choi BY, Min SH, Surh YJ. PLoS One. 2016 Jan 19;11(1):e0147038. doi: 10.1371/journal.pone.0147038. eCollection 2016. Erratum in: PLoS One. 2016;11(3):e0151517. PMID: 26784107 by RO JF TM

Processing of macromolecular heparin by heparanase. Gong F, Jemth P, Escobar Galvis ML, Vlodavsky I, Horner A, Lindahl U, Li JP. J Biol Chem. 2003 Sep 12;278(37):35152-8. Epub 2003 Jul 1. PMID: 12837765 by FK RM NM

●2017年秋学期  論文紹介はなし

●2017年春学期

The protein level and transcription activity of activating transcription factor 1 is regulated by prolyl isomerase Pin1 in nasopharyngeal carcinoma progression. Huang GL, Liao D, Chen H, Lu Y, Chen L, Li H, Li B, Liu W, Ye C, Li T, Zhu Z, Wang J, Uchida T, Zou Y, Dong Z, He Z. Cell Death Dis. 2016 Dec 29;7(12):e2571. doi: 10.1038/cddis.2016.349. PMID: 28032861 by HK

TASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer. van Geldermalsen M, Wang Q, Nagarajah R, Marshall AD, Thoeng A, Gao D, Ritchie W, Feng Y, Bailey CG, Deng N, Harvey K, Beith JM, Selinger CI, O'Toole SA, Rasko JE, Holst J. Oncogene. 2016 Jun 16;35(24):3201-8. doi: 10.1038/onc.2015.381. Epub 2015 Oct 12. PMID: 26455325 by MS

PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models. Dredge K, Hammond E, Handley P, Gonda TJ, Smith MT, Vincent C, Brandt R, Ferro V, Bytheway I. Br J Cancer. 2011 Feb 15;104(4):635-42. doi: 10.1038/bjc.2011.11. Epub 2011 Feb 1. PMID: 21285983 by MI MU MN

Cell surface localization of heparanase on macrophages regulates degradation of extracellular matrix heparan sulfate. Sasaki N, Higashi N, Taka T, Nakajima M, Irimura T. J Immunol. 2004 Mar 15;172(6):3830-5. PMID: 15004189 by YS SS NS

Biochemical characterization of the active heterodimer form of human heparanase (Hpa1) protein expressed in insect cells. McKenzie E, Young K, Hircock M, Bennett J, Bhaman M, Felix R, Turner P, Stamps A, McMillan D, Saville G, Ng S, Mason S, Snell D, Schofield D, Gong H, Townsend R, Gallagher J, Page M, Parekh R, Stubberfield C. Biochem J. 2003 Jul 15;373(Pt 2):423-35. PMID: 12713442 by FA AK AF

Heparanase expression in B16 melanoma cells and peripheral blood neutrophils before and after extravasation detected by novel anti-mouse heparanase monoclonal antibodies. Komatsu N, Waki M, Sue M, Tokuda C, Kasaoka T, Nakajima M, Higashi N, Irimura T. J Immunol Methods. 2008 Feb 29;331(1-2):82-93. Epub 2007 Dec 27. PMID: 18162185 by HO SS SS

The Heparanase Inhibitor PG545 Attenuates Colon Cancer Initiation and Growth, Associating with Increased p21 Expression. Singh P, Blatt A, Feld S, Zohar Y, Saadi E, Barki-Harrington L, Hammond E, Ilan N, Vlodavsky I, Chowers Y, Half E. Neoplasia. 2017 Mar;19(3):175-184. doi: 10.1016/j.neo.2016.12.001. Epub 2017 Jan 29. PMID: 28147305 by RY SY YY

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