kamei@hoshi.ac.jp

生年月日 昭和31年2月7日
学 歴 昭和53年 3月 星薬科大学卒業
昭和53年 4月 星薬科大学大学院博士前期課程入学
昭和55年 3月 同  修了(薬学修士)
昭和55年 4月 星薬科大学大学院博士後期課程入学
昭和58年 3月 同  修了(薬学博士)
職 歴 昭和58年 4月 星薬科大学助手
平成 7年 4月 星薬科大学講師
平成11年 7月 星薬科大学助教授
平成14年10月 星薬科大学教授
現在に至る
資 格 薬剤師
学会活動 日本薬理学会(学術評議員),日本薬学会,日本神経精神薬理学会(評議員), 鎮痛薬・オピオイドペプチド研究会(世話人), 日本アルコール・薬物医学会,日本東洋医学会, American Diabetes Association, The New York Academy of Sciences,Society for Neuroscience, 2003年度鎮痛薬・オピオイドペプチド研究会代表世話人
その他 国際協力事業団,ビルマ国製薬研究開発センタ−プロジェト専門家チ−ムリ−ダ−としてビルマ国ラング−ンに出張(昭和59年7月1日より昭和60年7月10日)

【原著論文】

1. 柳浦才三,細川友和,北川晴美,亀井淳三,三澤美和:
咳嗽反射に及ぼす末梢気道反応の影響
日本薬理学雑誌 76, 709-716(1980)

2. 木口百合子,後藤和利,高野一夫,西川嘉伸,八反丸善文,宮川政昭,亀井淳三,福原武彦:
微生物二次代謝物に由来する難病治療薬(E-64)の呼吸,循環機能および脳波に及ぼす影響
東京慈恵会医科大学雑誌 96, 701-711(1981)

3. Yanaura, S., Kamei, J., Goto, K., Hosokawa, T., Misawa, M. and Hukuhara, T., Jr.:
Analysis of efferent discharges of the phrenic nerve during the cough reflex.
The Japanese Journal of Pharmacology 32, 795-801(1982)

4. 柳浦才三,亀井淳三,後藤和宏,細川友和,平森為雄,三澤美和,福原武彦:
咳嗽反反射における横隔神経遠心性発射活動の計量的解析
日本薬理学雑誌 79, 543-550(1982)

5. 細川友和,亀井淳三,三澤美和,柳浦才三,福原武彦:
咳嗽反射時の呼吸中枢神経機構に及ぼす鎮咳薬の影響
日本薬理学雑誌 80, 367-374(1982)

6. 高野一夫,福原武彦,亀井淳三:
Fominoben およびその代謝産物の呼吸中枢神経機構に及ぼす影響
東京慈恵会医科大学雑誌 97, 848-859(1982)

7. Hosokawa, T., Kamei, J., Misawa, M., Yanaura, S. and Hukuhara, T., Jr.:
Effects of psychotropics on the periodic fluctuation in EEG synchronized with respratory rythms during the cough reflex.
The Japanese Journal of Psychopharmacology 3, 37-43(1983)

8. Yanaura, S., Mizuno, H., Goto, K., Kamei, J., Hosokawa, T., Ohtani, K. and Misawa, M.:
Effects of 8-(2-fluoroethyl)-3 -hydroxy-1 H,5 H-tropaniumbromide benzilate (Ba598Br) on allergy- and drug-induced asthmas.
The Japanese Journal of Pharmacology 33, 971-982(1983)

9. Yanaura, S., Fujikura, H., Hosokawa, T., Kitagawa, H., Kamei, J. and Misawa, M.:
Antitussive effect of RU-20201−Central and peripheral actions.
The Japanese Journal of Pharmacology 34, 289-298(1984)

10. Hosokawa, T., Goto, K., Kamei, J., Ohtani, K., Misawa, M. and Yanaura, S.:
Analysis of vagal reflex tracheal constriction in the dog.
The Japanese Journal of Pharmacology 36, 241-248(1984)

11. 三澤美和,細川友和,亀井淳三,柳浦才三,藤井祐一,渡辺 潔,上原美奈子,笠間俊男:
鎮痙薬Oxybutynin hydrochloride の心血管系に対する作用
日本薬理学雑誌 84, 395-406(1984)

12. 三澤美和,亀井淳三,小寺秀治,柳浦才三:
アルコールの臨床薬理(II) −ウィスキ− の効果−
臨床薬理 15, 149-150(1984)

13. 松元 俊,新家 真,高橋正弥,吉井利郎,亀井淳三,鈴木 勉,柳浦才三:
Dextran を含んだ潅流液の犬眼血液−房水柵に及ぼす影響
あたらしい眼科 2, 285-287(1985)

14. 亀井淳三,細川友和,柳浦才三,福原武彦:
鎮咳薬の作用に及ぼすnaloxoneの影響
日本薬理学雑誌 87, 641-648(1986)

15. Kamei, J., Hosokawa, T., Yanaura, S. and Hukuhara, T., Jr.:
Effects of methysergide on the cough reflex.
The Japanese Journal of Pharmacology 42, 450-452(1986)

16. Kamei, J., Hosokawa, T., Yanaura, S. and Hukuhara, T.:
Involvement of serotonergic mechanisms in the cough reflex.
The Japanese Journal of Pharmacology 42, 531-538(1986)

17. Kamei, J., Hukuhara, T. and Kasuya, Y.:
Dopaminergic control of the cough reflex as demonstrated by the effects of apomorphine.
European Journal of Pharmacology 141, 511-513(1987)

18. Kamei, J., Ogawa, M. and Kasuya, Y.:
Monoamines and the mechanisms of action of antitussive drugs in rats.
Archives internationales et de Therapie 290, 117-127 (1987)

19. Kamei, J. and Kasuya, Y.:
Effects of double-enkephalin (biphalin), an enkephalin analogue, on respiration and the cough reflex in rats.
Journal of Pharmacobio-dynamics 11, 645-650(1988)

20. Kamei, J., Ogawa, M. and Kasuya, Y.:
Supersensitivity to the respiratory-depressant and antitussive effect of dihydrocodeine in 5,7-dihydroxytryptamine-treated rats.
European Journal of Pharmacology 153, 305-308(1988)

21. 粕谷 豊,土屋賀生,小川 勝,末永 浩,深野竜史,宮田則之,森 辰也,荒井洋子,杉崎勝義,谷原裕章,西山浩史,森 智子,亀井淳三,細川友和,鎌田勝雄:
遺伝子組み換え・ヒト成長ホルモン製剤SJ−0011の一般薬理作用
薬理と治療 17, 67-87(1989)

22. Kamei, J., Ogawa, M. and Kasuya, Y.:
Effects of GABA antagonists on the pentobarbital-induced depression of respiration and cough in rats.
Pharmacology, Biochemistry and Behavior 32, 357-360(1989)

23. Kamei, J., Tanihara, H., Igarashi, H. and Kasuya, Y.:
Effects of N-methyl-D-aspartate antagonists on the cough reflex.
European Journal of Pharmacology 168, 153-158(1989)

24. Kamei, J., Mori, T., Ogawa, M. and Kasuya, Y.:
Subsensitivity to the cough-depressant effects of opioid and non-opioid antitussives in morphine-dependent rats: relationship to central serotonin function.
Pharmacology, Biochemistry and Behavior 34, 595-598(1989)

25. Kamei, J., Ogawa, M. and Kasuya, Y.:
Development of supersensitivity to substance P in the spinal cord of the streptozotocin-induced diabetic rats.
Pharmacology, Biochemistry and Behavior 35, 473-475(1990)

26. Kamei, J., Mori, T. and Kasuya, Y.:
Effects of L-tryptophan on the effects of antitussives.
Journal of Pharmacobio-dynamics 13, 231-237(1990)

27. Misawa, M., Takahashi, Y., Kamei, J., Hosokawa, T. and Yanaura, S.:
Inhibitory modulation on the reflex tracheal constriction induced by afferent vagal stimulation.
The Japanese Journal of Pharmacology 53, 506-509(1990)

28. Kamei, J., Tanihara, H. and Kasuya, Y.:
Antitussive effects of two specific -opioid agonists,U-50,488H and U-62,066E, in rats.
European Journal of Pharmacology 187, 281-286(1990)

29. Kamei, J., Mori, T. and Kasuya, Y.:
Effects of L-tryptophan on the development of tolerance to the antitussive effects of dihydrocodeine.
The Japanese Journal of Pharmacology 55, 403-406(1991)

30. Kamei, J., Ohhashi, Y., Aoki, T. and Kasuya, Y.:
streptozotocin-induced diabetes in mice reduces the nociceptive threshold, as recognized after application of noxious mechanical stimuli but not of thermal stimuli.
Pharmacology, Biochemistry and Behavior 39, 541-544(1991)

31. Kamei, J., Tanihara, H. and Kasuya, Y.:
The abilities of specific -opioid agonists, U-50,488H and U-62,066E, to cause antitussive tolerance was lower than that of morphine.
The Japanease Journal of Pharmacology 56, 557-561(1991)

32. Kamei, J., Mori, T., Igarashi, H. and Kasuya, Y.:
Effects of 8-hydroxy-2-(di-n-propylamino) tetralin, a selective agonist of 5-HT1A receptors, on the cough reflex in rats.
European Journal of Pharmacology 203, 253-258(1991)

33. Kamei, J., Tanihara, H. and Kasuya, Y.:
Modulation of -mediated antitussive activity in rats by a agonist.
European Journal of Pharmacology 203, 153-156(1991)

34. Kamei, J., Ogawa, M., Ohhashi, Y. and Kasuya, Y.:
Alteration in the potassium-evoked release of substance P from the spinal cord of streptozotocin-induced diabetic rats in vitro.
General Pharmacology 22, 1093-1096(1991)

35. Kamei, J., Igarashi, H. and Kasuya, Y.:
Modulation by serotonin of glutamate-induced lethality in mice.
Research Communications in Chemical Pathology and Pharmacology 74, 167-184(1991)

36. Kamei, J., Kawashima, N. and Kasuya, Y.:
Naloxone-induced analgesia in diabetic mice.
European Journal of Pharmacology 210, 339-341(1992)

37. Kamei, J., Ohhashi, Y., Aoki, T., Kawashima, N. and Kasuya, Y.:
Streptozotocin-induced diabetes selectively alters the potency of analgesia produced by -opioid agonists, but not by - and -opioid agonists.
Brain Research 571, 199-203(1992)

38. Kamei, J. and Kasuya. Y.:
Antitussive effects of Ca2+ channel antagonists.
European Journal of Pharmacology 212, 61-66(1992)

39. Kamei, J., Katsuma, K. and Kasuya, Y.:
Involvement of -opioid receptors in the antitussive effects of pentazocine.
Naunyn-Schmiedeberg's Archives of Pharmacology 345, 203-208(1992)

40. Kamei, J. and Kasuya, Y.:
The effect of hydrochlorothiazide on the enhanced coughing associated with treatment with enalapril.
European Journal of Pharmacology 213, 137-139(1992)

41. Kamei, J., Kawashima, N., Ohhashi, Y. and Kasuya, Y.:
Effects of diabetes on stress-induced analgesia in mice.
Brain Research 580, 180-184 (1992)

42. Kamei, J., Kawashima, N. and Kasuya, Y.:
Role of spleen or spleen products in the deficiency in morphine-induced analgeisa in diabetic mice.
Brain Research 576, 139-142(1992)

43. Kamei, J., Igarashi, H. and Kasuya, Y.:
Involvement of serotonergic mechanisms in the inhibitory effect of U-50,488H on glutamate-induced lethality in mice.
Research Communications in Chemical Pathology and Pharmacology 75, 357-360(1992)

44. Misawa, M., Takahashi, Y., Kamei, J. and Hosokawa, T.:
Inhibitory reflex during bronchoconstrictions induced by histamine and Ascaris suum antigen
The Japanese Journal of Pharmacology 58, 331-338(1992)

45. Kamei, J., Mori, T., Igarashi, H. and Kasuya, Y.:
Serotonin release in nucleus of the solitarytract and its modulation by antitussive drugs.
Research Communications in Chemical Pathology and Pharmacology 76, 371-374(1992)

46. Kamei, J., Tanihara, H. and Kasuya, Y.:
Modulation of -mediated antitussive activity in rats by a -agonist.
Research Communications in Chemical Pathology and Pharmacology 76, 375-378(1992)

47. Kamei, J., Aoki, T. and Kasuya, Y.:
Periaqueductal gray matter stimulation-produced analgesia in diabetic rats.
Neuroscience Letter 142, 13-16(1992)

48. Kamei, J., Hitosugi, H., Kawashima, N., Aoki, T., Ohhashi, Y. and Kasuya, Y.:
Antinociceptive effect of mexiletine in diabetic mice.
Research Communications in Chemical Pathology and Pharmacology 77, 245-248 (1992)

49. Kamei, J., Kawashima, N. and Kasuya, Y.:
Paradoxical analgesia produced by naloxone in diabetic mice is attributed to supersensitivity of -opioid receptors.
Brain Research 592, 101-105 (1992)

50. Kamei, J., Aoki, T., Hitosugi, H. and Kasuya, Y.:
Effects of morphine on responses of nociceptive ventrobasal thalamic neurons in diabetic rats.
The Japanese Journal of Pharmacology 60, 133-140(1992)

51. Kamei, J., Iwamoto, Y., Hitosugi, H., Kawashima, N., Misawa, M. and Kasuya, Y.:
Involvement of haloperidol-sensitive -receptors in antitussive effects.
European Journal of Pharmacology 224, 39-43(1992)

52. Kamei, J., Iwamoto, Y., Misawa, M. and Kasuya, Y.:
Antitussive effect of morphine is insensitive to ATP-sensitive potassium channel blocker.
Research Communications in Substances of Abuse 13, 341-344(1992)

53. Kamei, J., Kawashima, N. and Kasuya, Y.:
Serum glucose level-dependent and independent modulation of -opioid agonist-mediated analgesia in diabetic mice.
Life Sciences 52, 53-60(1993)

54. Kamei, J., Hitosugi, H. and Kasuya, Y.:
Nociceptive responses of intrathecally administered substance P and somatostatin in diabetic mice.
Life Sciences 52, PL31-PL36(1993)

55. Kamei, J., Hitosugi, H. and Kasuya, Y.:
Formalin-induced nociceptive response in diabetic mice.
Neuroscience letters 149, 161-164(1993)

56. Kamei, J., Iwamoto, Y., Kawashima, N., Suzuki, T., Nagase, H., Misawa, M. and Kasuya, Y.:
Possible involvement of 2-mediated mechanisms in -mediated antitussive activity in mouse.
Neuroscience Letters 149, 169-172(1993)

57. Kamei, J., Hitosugi, H., Misawa, M., Nagase, H. and Kasuya, Y.:
Cold water swim stress inhibits the nociceptive responses to intrathecally administered somatostatin, but not substance P.
Life Sciences 52, L169-L174(1993)

58. Kamei, J., Iwamoto, Y., Misawa, M., Nagase, H. and Kasuya, Y.:
Antitussive effect of - endorphin is mediated by -opioid receptors, but not by - or -opioid receptors.
European Journal of Pharmacology 233, 251-254(1993)

59. Kamei, J., Iwamoto, Y., Suzuki, T., Nagase, H., Misawa, M. and Y. Kasuya:
Differential modulation of -mediated antitussive activity by -opioid receptor agonists in mice.
European Journal of Pharmacology 234, 117-120(1993)

60. Kamei, J., Hitosugi, H., Kawashima, N. and Misawa, M. and Kasuya, Y.:
Effect of diabetes on the antinociceptive effect of inthrathecally administered endothelin-1 in mice.
Research Communicatiions in Chemical Pathology and Pharmacology 79, 209-217(1993)

61. Kamei, J., Hitosugi, H., Kawashima, N., Misawa, M. and Kasuya, Y.:
Antinociceptive effects of intrathecally administered endothelin-1 in mice.
Neuroscience Letters 153, 69-72(1993)

62. Kamei, J., Iwamoto, Y., Suzuki, T., Misawa, M., Nagase, H. and Kasuya, Y.:
Antitussive effects of - and -agonists in diabetic rats.
Neuroscience Letters 154, 65-68(1993)

63. Kamei, J., Hitosugi, H. and Kausya, Y.:
Effects of mexiletine on formalin-induced nociceptive responses in mice.
Research Communicatiions in Chemical Pathology and Pharmacology 80, 153-162(1993)

64. Kamei, J., Iwamoto, Y., Narita, M., Suzuki, T., Misawa, M. and Kasuya, Y.:
Antitussive effect of cromakalim, in rats, is not associated with adenosine triphosphate-sensitive K+ channels.
Research Communicatiions in Chemical Pathology and Pharmacology 80, 201-210(1993)

65. Kamei, J., Iwamoto, Y., Suzuki, T., Misawa, M., Nagase, H. and Kasuya, Y.:
The role of 2- receptor in the antitussive effect of morphine using the 1-receptor deficient CXBK mouse.
European Journal of Pharmacology 240, 99-101(1993)

66. Kamei, J., Kawashima, N., Suzuki, T., Misawa, M. and Kasuya, Y.:
The effects of cyclosporine on morphine-induced antinociception in diabetic mice.
Neuroscience Letters 158, 213-216(1993)

67. Kamei, J., Kawashima, N., Hitosugi, H., Misawa, M., Nagase, H. and Kasuya, Y.:
Effect of diabetes on the antinociceptive effect of -endorphin.
Brain Research 619, 76-80(1993)

68. Suzuki, T., Yoshiike, M., Funada, M., Kamei, J. and Misawa, M.:
Effects of cyclosporine A on the morphine-induced place preference.
Neuroscience Letters 160, 159-162(1993)

69. Kamei, J., Iwamoto, Y., Misawa, M. and Kasuya, Y.:
Effects of rimcazole, a specific antagonist of sites, on the antitussive effects of non-narcotic antitussive drugs.
European Journal of Pharmacology 242, 209-211(1993)

70. Kamei, J., Igarashi, H. Iwamoto, Y., Tanihara, H., Misawa, M. and Kasuya, Y.:
Antitussive effect of captopril, an angiotensin converting enzyme inhibitor, in the rat.
Research Communicatiions in Chemical Pathology and Pharmacology 81, 293-298 (1993)

71. Kamei, J., Iwamoto, Y., Suzuki, T., Misawa. M., Nagase, H. and Kasuya,Y.:
Antitussive effects of naltrindole, a selective -opioid receptor antagonist, in mice and rats.
European Journal of Pharmacology 249, 161-165(1993)

72. Kamei, J., Hitosugi, H. and Kasuya, Y.:
Cough induced activity of spirapril in rats.
General Pharmacology 24, 1443-1445(1993)

73. Narita, M., Takamori, K., Kawashima, N., Funada, M., Kamei, J., Suzuki, T., Misawa, M. and Nagase, H.:
Activation of central ATP-sensitive potassium channels produces the antinociception and spinal noradrenaline turnover-enhancing effect in mice.
Psychopharmacology 113, 11-14(1993)

74. Kamei, J., Hitosugi, H., Misawa, M., Nagase, H. and Kasuya, Y.:
-Opioid receptor-mediated swimming stress-induced antinociception in the formalin test.
Psychopharmacology 113, 15-18(1993)

75. Kamei, J., Kawashima, N., Iwamoto, Y., Suzuki, T., Nagase, H., Misawa, M. and Kasuya, Y.:
The effect of chronic treatment with naltrindole, a selective -opioid antagonist, on -opioid
receptor-mediated antinociception in diabetic mice.
Psychopharmacology 113, 167-171(1993)

76. Kamei, J., Kawashima, N., Narita, M., Suzuki, T., Misawa, M. and Kasuya, Y.:
Reduction in ATP-sensitive potassium channel-mediated antinociception in diabetic mice.
Psychopharmacology 113, 318-321(1994)

77. Kamei, J., Iwamoto, Y., Suzuki, T., Misawa, M., Kasuya, Y., Nagase, H., Okutomi, T., Soma, G. and Mizuno, D.:
Antinociceptive effect of lipopolysaccharide from Pantoea agglomerans in diabetic mice.
European Journal of Pharmacology 251, 95-98(1994)

78. Kamei, J., Iwamoto, Y., Suzuki, T., Misawa, M., Nagase, H. and Kasuya, Y.:
Involvement of 1-opioid receptor antagonism in the antitussive effect of -opioid receptor antagonists.
European Journal of Pharmacology 251, 291-294(1994)

79. Kamei, J., Iwamoto, Y., Misawa, M., Nagase, H. and Kasuya, Y.:
Streptozotocin-induced diabetes selectively reduces the antinociceptive effect which mediated by 1-opioid receptors, but not by 2-opioid receptors.
Neuroscience Letters 165, 141-143(1994)

80. Kamei, J., Iwamoto, Y., Misawa, M., Nagase, H. and Kasuya, Y.:
Antitussive effect of Met- enkephalin-Arg6-Phe7 in mice.
European Journal of Pharmacology 253, 293-296 (1994)

81. Kamei, J., Iwamoto, Y., Misawa, M., Nagase, H. and Kasuya, Y.:
Antinociceptive effect of L-arginine in diabetic mice.
European Journal of Pharmacology 254, 113-117 (1994)

82. Kamei, J., Iwamoto, Y., Hitosugi, H., Misawa, M. Nagase, H. and Kasuya, Y.:
Differential mediation of forced swimming stress-induced antinociception by -opioid receptor subtypes in diabetic mice.
Life Sciences 54, PL425-PL430 (1994)

83. Kamei, J., Iwamoto, Y., Suzuki, T., Misawa, M., Kasuya, Y., Okutomi, T., Soma, G. and Mizuno, D.:
Suppression of hyperalgesia in streptozotocin-induced diabetic mice by a lipopolysaccharide from Pantoea agglomerans.
Biological & Pharmaceutical Bulletin 17, 632-634 (1994)

84. Kamei, J., Iwamoto, Y., Misawa, M., Nagase, H. and Kasuya, Y.:
Effects of diabetes on the antinociceptive effect of ( )pentazocine in mice.
Research Communicatiions in Chemical Pathology and Pharmacology 84, 105-110 (1994)

85. Kamei, J., Iwamoto, Y., Misawa, M., Nagase, H. and Kasuya, Y.:
Streptozotocin-induced diabetes selectively enhances the antinociceptive effect which mediated by 1-opioid receptors, but not by 2-opioid receptors.
Life Sciences 55, PL121-PL126 (1994)

86. Kamei, J., Iwamoto, Y., Misawa, M., Nagase, H. and Kasuya, Y.:
Antitussive effect of ( ) pentazocine in diabetic mice is mediated by -sites, but not by - and -opioid receptors.
Japanese Journal of Psychopharmacology 14, 147-152 (1994)

87. Kamei, J., Iwamoto, Y., Suzuki, T., Misawa, M., Nagase, H. and Kasuya, Y.:
Antitussive effect of dihydroetorphine in mice.
European Journal of Pharmacology 260, 257-259 (1994)

88. Kamei, J., Ohsawa, M., Misawa, M., Nagase, H. and Kasuya, Y.:
Effects of diabetes on morphine-induced Straub tail reaction in mice.
Neuroscience Letters 178, 66-68 (1994)

89. Kamei, J., Saitoh, A., Iwamoto, Y., Funada, M., Suzuki, T., Misawa, M. and Kasuya, Y.:
Effects of diabetes on spontaneous locomotor activity in mice.
Neuroscience Letters 178, 69-72 (1994)

90. Suzuki, T., Yoshiike, M., Funada, M., Kamei, J., M.sawa, M., Nagase, H.:
Effect of opioid antagonists on the morphine-induced place preference in ddY and CXBK mice.
Regulatory Peptides S1, S45-S46 (1994)

91. Kamei, J., Kawashima, N., Iwamoto, Y., Suzuki, T., Nagase, H., Misawa, M. and Kasuya, Y.:
The effect of chronic treatment with naltrindole on -opioid receptor-mediated antinociception in diabetic mice.
Regulatory Peptides S1, S85-S86 (1994)

92. Arakawa, K., Akami, T., Okamoto, M., Akioka, K., Lee, P.C., Sugano, Y., Kamei, J., Suzuki, T., Nagase, H., Tsuchihashi, Y. and Oka, T.:
Prolongation of heart xenograft survival in the NK- deficient rat.
Transplantation Proceedings 26, 1266-1267 (1994)

93. Kamei, J., Iwamoto, Y. and Misawa, M.:
Cough induced activity of (-)-(2S, 3aR, 7aS)-1-[(S)-N- [(S)-1-ethoxycarbonyl-3-phenylpropyl]-alanyl]hexahydro-2-indolinecarboxylic acid (trandolapril) in guinea pigs.
Research Communicatiions in Molecular Pathology and Pharmacology 85, 105-108 (1994)

94. Suzuki, T., Yoshiike, M., Mizoguchi, H., Kamei, J., Misawa, M. and Nagase, H.:
Blockade of - opioid receptors prevents morphine-induced place preference in mice.
The Japanease Journal of Pharmacology 66, 131-137 (1994)

95. Kamei, J., Iwamoto, Y., Misawa, M., Nagase, H. and Kasuya, Y.:
Involvement of adenosine A1 receptors in antitussive effect.
Life Sciences 55, PL383-PL388 (1994)

96. Kamei, J., Iwamoto, Y., Misawa, M., Nagase, H. and Kasuya, Y.:
Evidence for differential modulation of -opioid receptor-mediated antinociceptive and antitussive activities by spleen- derived factor(s) from diabetic mice.
Neuropharmacology 33, 1553-1558 (1994)

97. Kamei, J., Saitoh, A., Suzuki, T., Misawa, M., Nagase, H. and Kasuya, Y.:
Buprenorphine exerts its antinociceptive activity via 1-opioid receptors.
Life Sciences 56, PL285-PL290 (1995)

98. Kamei, J., Suzuki, T., Misawa, M., Nagase, H. and Kasuya, Y.:
Antinociceptive effect of dihydroetorphine in diabetic mice.
European Journal of Pharmacology 275, 109-113 (1995)

99. Kamei, J., Saitoh, A., Ohsawa, M., Suzuki, T., Misawa, M., Nagase, H. and Kasuya, Y.:
Antinociceptive effect of non-peptide -opioid receptor agonist, TAN-67, in diabetic mice.
European Journal of Pharmacology 276, 131-136 (1995)

100. Kamei, J., Ohsawa, M., Misawa, M., Nagase, H. and Kasuya, Y.:
The effect of diabetes on morphine-induced inhibition of gastrointestinal transit effect.
Japanese Journal of Psychopharmacology 15, 165-169 (1995)

101. Kamei, J., Ohsawa, M., Saitoh, A., Iwamoto, Y., Suzuki, T., Misawa, M., Nagase, H. and Kasuya, Y.:
Modification of -opioid receptor agonist-induced locomotor activity and development of morphine dependence by diabetes.
Journal of Pharmacology and Experimental Therapeutics 274, 700-706 (1995)

102. Kamei, J., Saitoh, A., Morita, K. and Nagase, H.:
Antagonistic effect of buiprenorphine on the antitussive effect of morphine is mediated via the activation of 1-opioid receptors.
Life Sciences 57, PL231-235 (1995)

103. Kamei, J., Saitoh, A. and Kasuya, Y.:
Involvement of 1-opioid receptors in the antinociceptive effects of mexiletine in mice.
Neuroscience Letters 196, 169-172 (1995)

104. Ito, K., Ito, K., Sawada, Y., Kamei, J., Misawa, M. and Iga, T.:
Toxicodynamic analysis of cough and infulammatory reactions by angiotensin converting enzyme inhibitors in guinea- pig.
Journal of Pharmacology and Experimental Therapeutics 275, 920-925 (1995)

105. Kamei, J. and Saitoh, A.:
Involvement of dopamine D2 receptor-mediated functions in the modulation of morphine-induced antinociception diabetic mouse.
Neuropharmacology 35, 273-278 (1996)

106. Kamei, J., Morita, K., Saitoh, A. and Suzuki, T.:
Antitussive effect of morphine in the DA- bg/bg (Beige) rat.
European Journal of Pharmacology 300, 75-78 (1996)

107. Kamei, J. and Saitoh, A:
Modification of the effects of 7-OH-DPAT, a dopamine D3 receptor agonist, on morphine-induced hyperlocomotion by diabetes.
Life Science 59, 773-780 (1996)

108. Kamei, J. Ohsawa, M. and Nagse, H.:
Possible involvement of 2-opioid receptor-mediated mechanisms in morphine-induced enhancement of the pentobarbital-induced loss of the righting reflex in the mouse.
Life Sciences 59, PL349-PL353 (1996)

109. Kamei, J. and Morita K.:
Antitussive effect of moguisteine, a novel peripheral non-narcotic antitussive drugs, on the enhanced coughing associated with enalapril in guinea pig.
European Journal of Pharmacology 312, 235-239 (1996)

110. Kamei, J. and Saitoh, A:
Role of spleen or spleen products in the reduced locomotor-enhancing effect of morphine in diabetic mice.
Neuroscience Letters 210, 57-60 (1996)

111. Kamei, J., Suzuki, T. and Nagase, H:
Agonist and Antagonist properties of dihydroetorphine for -opioid receptors in mice.
Neuroscience Letters 215, 87-90 (1996)

112. Kamei, J. and Ohsawa, M.:
Effects of diabetes on the methamphetamine-induced place preference in mice.
European Journal of Pharmacology 318, 251-256 (1996)

113. Narita, M., Ohsawa, M., Mizoguchi, K., Kamei, J. and Tseng, L.F.:
Pretreatment with protein kinase C activator phorbol 12,13-dibutyrate attenuates the antinociception induced by - but not -opioid receptor agonist in the mouse.
Neurosciernce 76, 291-298 (1997)

114. Tseng, L.F., Narita, M., Mizoguchi, H., Kawai, K., Mizusuna, A., Kamei, J., Suzuki, T. and Nagase, H.:
1-opioid receptor-mediated antinociceptive properties of a nonpeptidic -opioid receptor agonist, (-)TAN-67 in the mouse spinal cord.
Journal of Pharmacology and Experimental Therapeutics 280, 600-605 (1997)

115. Kamei, J. and Ohsawa, M.:
Role of noradrenergic functions in the modulation of naloxone-precipitated withdrawal jumping in morphine-dependent mice by diabetes.
Life Sciences 60, PL223-PL228 (1997)

116. Kamei, J. and Saitoh, A.:
Evidence for the modulation of spontaneous locomotor activity by higher serum glucose levels and/or spleen-derived factor(s) in diabetic mice.
Life Sciences 60, 1699-1708 (1997)

117. Kamei, J., Sodeyama, M., Tsuda, M., Suzuki, T. and Nagase, H.:
Antinociceptive effect of buprenorphine in 1-opioid receptor deficient CXBK mice.
Life Sciences 60, PL333-PL337 (1997)

118. Kamei, J., Kawai, K., Mizusuna, A., Saitoh, A., Morita, K., Narita, M., Tseng, L.F. and Nagase, N.:
Supraspinal 1-opioid receptor-mediated antinociceptive properties of the nonpeptidic -opioid receptor agonist (-)TAN-67 in diabetic mice.
European Journal of Pharmacology 322, 27-30 (1997)

119. Kamei, J., Kashiwazaki, T. Hitosugi, H. and H. Nagase:
The role of spinal 1-opioid receptors in inhibiting the formalin-induced nociceptive response in diabetic mice.
European Journal of Pharmacology 326, 31-36 (1997)

120. Hirakawa, T., Obata, Y., Takayama, K., Kamei, J., Soa, Y., Kutsuma, T., Honda, T. and Nagai, T.:
Pharmacokinetic behavior and pharmacological activity of diclifenac modified by phospholipid-like compound.
Drug Delivery System 12, 167-173 (1997)

121. Ohsawa M. and Kamei, J.:
Pretreatment with the protein kinase C activator phorbol 12,13-dibutyrate attenuates the ethanol-induced loss of the righting reflex in mice: modification by diabetes.
Brain Research 764, 244-248 (1997)

122. Kamei, J. and Ohsawa, M.:
Effect of diabetes on cocaine-induced place preference.
The Japanese Journal of Pharmacology 75, 299-302 (1997)

123. Kamei, J., Ohsawa, M., Suzuki, T. and Nagase, H.:
Modification of morphine-induced place preference by diabetes.
European Journal of Pharmacology 337, 137-145 (1997)

124. Kamei, J., Xiao, P., Ohsawa, M., Kubo, H., Higashiyama, K., Takahashi, H., Li, J., Nagase, H. and Ohmiya, S.:
Antinociceptive effects of (+)-matrine in mice.
European Journal of Pharmacology 337, 223-226 (1997)

125. Kamei, J., Sodeyama, M., Ohsawa, M., Kimura M. and Tanaka, S.:
Modulation by serum glucose levels to morphine-induced antinociceptive effect on C57BL/KsJ-db/db mice.
Life Sciences 62, PL1-6 (1997)

126. Ohsawa, M. and Kamei, J.:
Possible involvement of protein kinase C on the attenuation of DAMGO-induced antinociceptive effect in diabetic mice.
Euroepan Journal of Pharmacology 339, 27-31 (1997)

127. Saitoh, A., Morita, K., Sodeyama, M. and Kamei, J.:
Effects of the experimental diabetes on D1 dopamine receptor-mediated locomotor enhancing activity in mice.
Pharmacology, Biochemistry and Behavior 60, 161-166 (1998)

128. Kamei, J., Ohsawa, M., Sodeyama, M., Kimura, M. and Tanaka, S.:
Intraventricular insulin reduces the antinociceptive effect of DAMGO in mice.
European Journal of Pharmacology 345, 171-174 (1998)

129. Kamei, J., Morita, K., Kashiwazaki, T. and Ohsawa, M.:
Antitussive effect of moguisteine on allergic coughs in the guinea pig.
European Journal of Pharmacology 347, 253-256 (1998)

130. Ohsawa, M., Kashiwazaki, T. and Kamei, J.:
Modulation of the formalin-induced nociceptive response by diabetes: possible involvement of protein kinase C.
Brain Research 803, 198-203 (1998)

131. Ohsawa, M. and Kamei, J.:
Role of intracellular calcium in modification of - and -opioid receptor-mediated antinociception by diabetes in mice.
Journal of Pharmacology and Experimental Therapeutics 286, 780-787 (1998)

132. Suzuki, Y., Goto, K., Ishige, A., Komatsu, Y. and Kamei, J.:
Effect of Gosha-jinki-gan, a Kampo medicine, on enhanced pletelet aggregation in streptozotocin-induced diabetic rats.
The Japanese Journal of Pharmacology 78, 87-91 (1998)

133. Suzuki, Y., Goto, K., Ishige, A., Komatsu, Y. and Kamei, J.:
Effect of Gosha-jinki-gan, a kampo medicine (Japanese Herbal Medicine), on tissue blood flow in streptozotocin-induced diabetic rats.
Methods and Findings in Experimental and Clinical Pharmacology 20, 321-328 (1998)

134. Ohsawa, M. and Kamei, J.:
Possible involvement of protein kinase C in the attenuation of the morphine-induced Straub tail reaction in diabetic mice.
European Journal of Pharmacology 362, 47-51 (1998)

135. Ohsawa, M. and Kamei, J.:
Role of intracellular calcium on the modulation of naloxone- precipitated withdrawal jumping in morphine-dependent mice by diabetes.
Brain Research 815, 424-430 (1999)

136. Suzuki, Y., Goto, K., Ishige, A., Komatsu, Y. and Kamei, J.:
Antinociceptive effect of Gosha- jinki-gan, a Kampo medicine, in streptozotocin-induced diabetic rats.
The Japanese Journal of Pharmacology 79, 169-175 (1999)

137. Ohsawa, M. and Kamei, J.:
Modification of the expression of naloxone-precipitated withdrawal signs in morphine dependent mice by diabetes: possible involvement of protein kinas C.
The Japanese Journal of Pharmacology 79, 303-311 (1999)

138. Suzuki, Y., Goto, K., Ishige, A., Komatsu, Y. and Kamei, J.:
Antinociceotive mechanisms of Gosha-jinki-gan in streptozotocin-induced diabetic animals: Role of nitric oxide in the periphery.
The Japanese Journal of Pharmacology 79, 387-391 (1999)

139. Kamei, J., Kashiwazaki, T., Hitosugi, H. and Nagase H.:
Algogenic mediator-induced nociceptive response in diabetic mice.
European Journal of Pharmacology 369, 319-323 (1999)

140. Kamei, J., Ohsawa, M., Kashiwazaki, T. and Nagase, H.:
Antinociceptive effects of opioid receptor-like 1 agonist nociceptin/orphanin FQ in diabetic mice.
European Journal of Pharmacology 370, 109-116 (1999)

141. Xiao, P., Ohsawa, M., Kubo, H., Higashiyama, K., Nagase, H., Yan, Y., Li, J., Kamei, J., and Ohmiya, S.:
-Opioid receptor-mediated antinociceptive effects of stereoisomers and derivatives of (+)-matrine in mice.
Planta Medica 65, 230-233 (1999)

142. Ohsawa, M. and Kamei, J.:
Possible involvement of spinal protein kinase C in the thermal allodynia and hyperalgesia in diabetic mice.
European Journal of Pharmacology 372, 221-228 (1999)

143. Ohsawa, M., Tanaka, S. and Kamei, J.:
Possible involvement of the activation of protein kinase C in intraventricular insulin induced attenuation of the antinociceptive effect of [D-Ala2, N-MePhe4, Gly-ol5]enkephalin in mice.
European Journal of Pharmacology 373, 181-186 (1999)

144. Sakakibara, I., Terabayashi, S., Kubo, M., Higuchi, M., Komatsu, Y., Okada, M., Taki, K. and Kamei, J.:
Effect on locomotion of indole alkalods from the hooks of Uncaria plants.
Phytomedicine 6, 163-168 (1999)

145. Ohsawa, M. and Kamei, J.:
Role of intracellular calcium in thermal allodynia and hyperalgesia in diabetic mice.
Brain Research 833, 278-281 (1999)

146. Ohsawa, M. and Kamei, J.:
Modification of the effect of diazepam on the propofol-induced loss of the righting reflex in mice by diabetes.
Brain Research 833, 282-285 (1999)

147. Hitosugi, H., Kashiwazaki, T., Ohsawa, M. and Kamei, J.:
Effects of mexiletine on algogenic mediator-induced nociceptive responses in mice.
Methods and Findings in Experimental and Clinical Pharmacology 21, 409-413 (1999)

148. Tsuji, M., Narita, M., Mizoguchi, H., Narita, M., Ohsawa, M., Kamei, J., Nagase, H., Takeda, H., Matsumiya, T. and Tseng, L.F.:
Region-dependent G-protein activation by -, 1-, and 2-opioid receptor agonists in the brain: comparison between the midbrain and forbrain.
Life Sciences 65, PL233-239 (1999)

149. Kamei, J., Ohsawa, M., Suzuki, T., Saitoh, A., Endoh, T., Narita, M., Tseng, L.F. and Nagase, H.:
The modulatory effect of (+)-TAN-67 on the antinociceptive effects of the nociceptin/ orphanin FQ in mice.
European Journal of Pharmacology 383, 241-247 (1999)

150. Kamei, J., Taki, K., Ohsawa, M. and Nagase, H.:
Involvement of spinal 1-opioid receptors in forced walking stress-induced antinociception in mice.
Methods and Findings in Experimental and Clinical Pharmacology 21, 595-598 (1999)

151. Kamei, J., Morita, K., Ohsawa, M. and Onodera, K.:
Effects of epinastine on the antitussive and rewarding effects of dihydrocodeine in mice.
Methods and Findings in Experimental and Clinical Pharmacology 21, 663-668 (1999)

152. Endoh, T., Tajima, A., Suzuki, T., Kamei, J., Narita, M., Tseng, L.F. and Nagase, H.:
Characterization of the antinociceptive effects of TRK820 in the rat.
European Journal of Pharmacology 387, 133-140 (2000)

153. Kamei, J.:
Antinociceptive effects of the enantiomorphs of mexiletine and its main metabolite in streptozotocin-induced diabetic mice. (in Japanese)
Japanese Journal of Psychopharmacology 20, 11-17 (2000)

154. Kamei, J., Ohsawa, M. and Hitosugi, H.:
Effect of diabetes on bradykinin-induced thermal hyperalgesia in mice.
European Journal of Pharmacology 390, 113-118 (2000)

155. Kamei, J., Zushida, K., Ohsawa, M. and Nagase, H.:
The antinociceptive effects of endomorphin-1 and endomorphin-2 in diabetic mice.
European Journal of Pharmacology 391, 91-96 (2000)

156. Kamei, J., Taki, K., Ohsawa, M. and Hitosugi, H.:
Modulation of the formalin-induced nociceptive response by diabetes: possible involvement of intracellular calcium.
Brain Research 862, 257-261 (2000)

157. Kamei, J. and Ohsawa, M.:
Socio-psychological stress-induced antinociception in diabetic mice.
Psychopharmacology 149, 397-400 (2000)

158. Morita, K. and Kamei, J.:
Involvement of ATP-sensitive K+ channels in the antitussive effect of moguisteine.
European Journal of Pharmacology 395, 161-164 (2000)

159. Ohsawa, M., Mizoguchi, H., Narita, M., Narita, M., Kamei, J., Nagase, H. and Tseng, L.F.:
Effects of a -opioid receptor agonist on G-protein activation in streptozotocin-induced diabetic mice.
European Journal of Pharmacology 401, 55-58 (2000)

160. Pieper G.M., Mizoguchi, H., Ohsawa, M. Kamei, J., Nagase, H. and Tseng, L.F.:
Decreased opioid-induced antinociception but unaltered G-protein activation in the genetic-diabetic NOD mouse.
European Journal of Pharmacology 401, 375-379 (2000)

161. Kubo, H., Kobayashi, J., Higashiyama, K., Kamei, J., Fujii, Y. and Ohmiya, Y.:
The hypoglycemic effect of (7R*, 9aS*)-7-phenyl-octahydroquinolizin-2-one in mice.
Biological and Pharmaceutical Bulletin 23, 1114-1117 (2000)

162. Kamei, J. and Zushida, K.:
Effect of mexiletine on thermal allodynia and hyperalgesia in diabetic mice.
The Japanese Journal of Pharmacology 84, 89-92 (2000)

163. Onodera, K., Shinoda, H., Zushida, K., Taki, K. and Kamei, J.:
Antinociceptive effect induced by intraperitoneal administration of vitamin K2 (menatetrenone) in ICR mice.
Life Sciences 68, 91-97 (2000)

164. Yajima, Y., Narita, M., Tsuda, M., Imai, S., Kamei, J., Nagase, H. and Suzuki, T.:
Modulation of NMDA- and (+)TAN-67-induced nociception by GABAB receptors in the mouse spinal cord.
Life Sciences 68, 719-725 (2000)

165. Kamei, J. and Zushida, K.:
The role of spinal cholecystokinin B receptors in thermal allodynia and hyperalgesia in diabetic mice.
Brain Research 892, 370-375 (2001)

166. Kamei, J., Zushida, K., Nagase, H.:
Role of cholecystokinin in the reduction of endomorphin-2 induced antinociception in diabetic mice.
European Journal of Pharmacology 416, 95-99 (2001)

167. Endoh, T., Tajima, A., Izumimoto, N., Suzuki, T., Saitoh, A., Suzuki, T., Narita, M., Kamei, J., Tseng, L.F., Mizoguchi, H. and Nagase, H.:
TRK-820, a selective -opioid agonist, produces potent antinociception in cynomolgus monkeys.
The Japanese Journal of Pharmacology 85, 282-290 (2001)

168. Onodera, K., Zushida, K. and Kamei, J.:
Antinociceptive effect of vitamin K2 (menatetrenone) in diabetic mice.
The Japanese Journal of Pharmacology 85, 335-337 (2001)

169. Nagase, H., Yajima, Y., Fujii, H., Kaawamura, K., Narita, M., Kamei, J. and Suzuki, T.:
The Pharmacological profile of d opioid receptor ligands, (+) and (-)TAN67 on pain modulation.
Life Sciences 68, 2227-2231 (2001)

170. Kamei, J. and Nagase, H.:
Norbinaltorphimine, a selective -opioid receptor antagonist, induces an itch-associated response in mice.
European Journal of Pharmacology 418, 141-145 (2001)

171. Kamei, J., Ohsawa, M., Tsuji, M., Takeda, H. and Matsumiya, T.:
Effect of diabetes on the emotional behavior in hole-board test in mice.
The Japanese Journal of Pharmacology 86, 47-54 (2001)

172. Suzuki, Y., Goto, K., Shiizaki, K., Omiya, Y., Ishige, A., Komatsu, Y. and Kamei, J.:
Antinociceptive effect of U-50488H, a -opioid agonist, in streptozotocin-induced diabetic mice.
Journal of Pharmacy and Pharmacology 53, 521-526 (2001)

173. Kamei, J., Zushida, K., Morita, K., Sasaki, M. and Tanaka, S.:
Role of vanilloid VR1 receptor in thermal allodynia and hyperalgesia in diabetic mice.
European Journal of Pharmacology 422, 83-86 (2001)

174. Aragane, K., Kojima, K., Fujinami, K., Kamei, J. and Kusunoki, J.:
Effect of F-1394, an acyl-CoA: cholesterol acyltransferase inhibitor, on atherosclerosis induced by high cholesterol diet in rabbits.
Atherosclerosis 158, 139-145 (2001)

175. Kamei, J., Sasaki, M., Zushida, K., Tanaka, S.:
Nociception and allodynia/hyperalgesia induced by intrathecal administration of fenvalerate.
The Japanese Journal of Pharmacology 86, 336-341 (2001)

176. Onodera, K., Shibata, M., Kojima, J., Kamei, J., Sogawa, N., Furuta, H. and Wachi, M.:
Toxicity of theophyline depends on plasma concentration by single and also repeated dosing in rats.
Pharmacological Research 44, 81-87 (2001)

177. Onodera, K., Takahashi, A., Mayanagi, H., Wakabayashi, H., Kamei, J. and Shinoda, H.:
Phenytoin-induced Bone Loss and Its Prevention with Alfacalcidol or Calcitriol in Growing Rats.
Calcified Tissue International 69, 109-116 (2001)

178. Nishigaki, R., Ito, A., Kamei, J., Takahashi, T. and Fujii, E.:
Risk factors for development of postoperative hypertension.
Methods and Findings in Experimental and Clinical Pharmacology 23, 203-207 (2001)

179. Togashi, Y., Umeuchi, H., Okano, K., Ando, N., Yoshizawa, Y., Honda, T., Kawamura, K., Endoh, T., Utsumi, J., Kamei, J., Tanaka, T. and Nagase, H.:
Antipruritic activity of the -opioid receptor agonist, TRK-820.
European Journal of Pharmacology 435, 259-264 (2002)

180. Isomae, K., Ishikawa, M., Ohta, M., Ogawa, Y., Hasegawa, H., Kohda, T., and Kamei, J.:
Effects of T-82 on cholinesterase activity and extracellular acetylcholine concentration in rat brain.
The Japanese Journal of Pharmacology 88, 206-212 (2002)

181. Saitoh, A., Onodera, K., Morita, K., Sodeyama, M. and Kamei, J.:
Prazosin inhibits the spontaneous locomotor activity in diabetic mice.
Pharmacology, Biochemistry & Behavior 72, 365-369 (2002)

182. Nishigaki, R., Ito, A., Kamei, J., Takahashi, T. and Fujii, E.:
Effect of nitroglycerin patch and sublingual administration of nifedipine in postoperative hypertension. (in Japanese)
Japanese Journal of Pharmaceutical Health Care and Sciences 28, 95-100 (2002)

183. Yamakawa, T., Tanaka, S., Yamakawa, Y., Kamei, J., Numaguchi, K., Motley, E.D., Inagami T.and Eguchi, S.:
Lysophosphatidylcholine activates extracellular signal-regulated kinases1/2 through reactive oxygen species in rat vascular smooth muscle cells.
Arteriosclerosis Thrombosis & Vascular Biology 22, 752-758 (2002)

184. Morita, K., Onodera, K. and Kamei, J.:
Inhaled pinacidil, an ATP-sensitive K+ channel opener, and moguisteine have potent antitussive effects in guinea pigs.
The Japanese Journal of Pharmacology 89, 171-175 (2002)

185. Zushida, K. and Kamei, J.:
Effect of MK-801 on the antinociceptive effect of DAMGO in diabetic mice.
European Journal of Pharmacology 448, 39-44 (2002)

186. Kamei, J., Iguchi, E., Sasaki, M., Zushida, K., Morita, K. and Tanaka, S.:
Modification of the fenvalerate-induced nociceptive response in mice by diabetes.
Brain Research 948, 17-23 (2002)

187. Onodera K, Takahashi A, Wakabayashi H, Kamei J, Sakurada S.
Effects of menatetrenone on the bone and serum levels of vitamin K2 (menaquinone derivatives) in osteopenia induced by phenytoin in growing rats.
Nutrition. 19(5): 446-450. (2003)

188. Kamei J, Onodera K, Kawaguchi M, Shibata M, Kagawa M, Wachi M, Kojima J.
Toxicological study of a new maintenance fluid, Veen 3G, in rats.
Methods Find Exp Clin Pharmacol. 24(8):493-496. (2002)

189. Zushida K, Onodera K, Kamei J.
Effect of diabetes on pinacidil-induced antinociception in mice.
Eur J Pharmacol. 453(2-3):209-215. (2002)

190. Kamei J, Morita K, Miyata S, Onodera K.
Effects of second generation of histamine H1 antagonists, cetirizine and ebastine, on the antitussive and rewarding effects of dihydrocodeine in mice.
Psychopharmacology 166(2):176-180. (2003)

191. Yamakawa T, Tanaka S, Kamei J, Kadonosono K, Okuda K.
Pitavastatin inhibits vascular smooth muscle cell proliferation by inactivating extracellular signal-regulated kinases 1/2.
J Atheroscler Thromb.10(1):37-42. (2003)

192. Isomae K, Morimoto S, Hasegawa H, Morita K, Kamei J.
Effects of T-82, a novel acetylcholinesterase inhibitor, on impaired learning and memory in passive avoidance task in rats.
Eur J Pharmacol.465(1-2):97-103. (2003)

193. Kamei J, Morita K, Saitoh A, Nagase H.
The antitussive effects of endomorphin-1 and endomorphin-2 in mice.
Eur J Pharmacol. 467(1-3):219-222. (2003)

194. Takahashi A, Onodera K, Kamei J, Sakurada S, Shinoda H, Miyazaki S, Saito T, Mayanagi H.
Effects of chronic administration of zonisamide, an antiepileptic drug, on bone mineral density and their prevention with alfacalcidol in growing rats.
J Pharmacol Sci. 91(4):313-318. (2003)

195. Kamei J, Nakamura R, Ichiki H, Kubo M.
Antitussive principles of Glycyrrhizae radix, a main component of the Kampo preparations Bakumondo-to (Mai-men-dong-tang).
Eur J Pharmacol. 469(1-3):159-163. (2003)

196. Kamei J, Miyata S, Morita K, Saitoh A, Takeda H.
Effects of selective serotonin reuptake inhibitors on immobility time in the tail suspension test in streptozotocin-induced diabetic mice.
Pharmacol Biochem Behav. 75(2):247-254. (2003)

197. Morita K, Kamei J.
Antitussive effect of WIN 55212-2, a cannabinoid receptor agonist.
Eur J Pharmacol. 474(2-3):269-272. (2003)

198. Yamakawa T, Tanaka S, Kamei J, Kadonosono K, Okuda K.
Phosphatidylinositol 3-kinase in angiotensin II-induced hypertrophy of vascular smooth muscle cells.
Eur J Pharmacol. 478(1):39-46. (2003)

199. Miyata S, Hirano S, Kamei J.
Diabetes attenuates the antidepressant-like effect mediated by the activation of 5-HT1A receptor in the mouse tail suspension test.
Neuropsychopharmacology. 29(3):461-469. (2004)

200. Tanaka SI, Yamakawa T, Kimura M, Aoki I, Kamei J, Okuda K, Mobbs C.
Daily nasal inoculation with the insulin gene ameliorates diabetes in mice.
Diabetes Res Clin Pract. 63(1):1-9. (2004)

201. Kamei J, Matsunawa Y, Miyata S, Tanaka S, Saitoh A.
Effects of nociceptin on the exploratory behavior of mice in the hole-board test.
Eur J Pharmacol. 489(1-2):77-87. (2004)

202. Saitoh A, Kimura Y, Suzuki T, Kawai K, Nagase H, Kamei J.
Potential anxiolytic and antidepressant-like activities of SNC80, a selective delta-opioid agonist, in behavioral models in rodents.
J Pharmacol Sci. 95(3):374-380. (2004)

203. Kamei J, Matsunawa Y, Saitoh A.
Antitussive effect of NS-398, a selective cyclooxygenase-2 inhibitor, in guinea pigs.
Eur J Pharmacol. 497(2):233-239. (2004)

204. Miyata S, Hirano S, Kamei J.
Diabetes inhibits the DOI-induced head-twitch response in mice.
Psychopharmacology (in press)

205. Kamei J, Saitoh A, Tamura N.
Effect of Mexiletine on Fenvalerate-Induced Nociceptive Response in Diabetic Mice.
J Pharmacol Sci. (in press)

204. Miyata S, Hirano S, Kamei J.
Diabetes inhibits the DOI-induced head-twitch response in mice.
Psychopharmacology (Berl). Dec 177(1-2):224-9. (2004)

205. Kamei J, Saitoh A, Tamura N.
Effect of Mexiletine on Fenvalerate-Induced Nociceptive Response in Diabetic Mice.
J Pharmacol Sci. Nov 96(3):280-5. (2004)

206. Takahashi A, Saito T, Mayanagi H, Kamei J, Onodera K.
Effects of the antiepileptics phenytoin and zonisamide on dentin formation and bone mineral density of the mandible in growing rats.
Methods Find Exp Clin Pharmacol. Dec;26(10):769-73. (2004)

207. Kamei J, Saitoh A, Asano T, Nakamura R, Ichiki H, Iiduka A, Kubo M.
Pharmacokinetic and pharmacodynamic profiles of the antitussive principles of Glycyrrhizae radix (licorice), a main component of the Kampo preparation Bakumondo-to (Mai-men-dong-tang).
Eur J Pharmacol. Jan 10;507(1-3):163-8. (2005)

208. Kamei J, Hirano S, Miyata S, Saitoh A, Onodera K.
Effects of first- and second-generation histamine-H1-receptor antagonists on the pentobarbital-induced loss of the righting reflex in streptozotocin-induced diabetic mice.
J Pharmacol Sci. Feb;97(2):266-72. (2005)

209. Higashiyama K, Takeuchi Y, Yamauchi T, Imai S, Kamei J, Yajima Y, Narita M, Suzuki T.
Implication of the descending dynorphinergic neuron projecting to the spinal cord in the (+)-matrine- and (+)-allomatrine-induced antinociceptive effects.
Biol Pharm Bull. 28(5):845-8. (2005)

210. Ohsawa M, Kamei J.
Modification of kappa-opioid receptor agonist-induced antinociception by diabetes in the mouse brain and spinal cord.
J Pharmacol Sci. 98(1):25-32. (2005)

211. Saitoh A, Yoshikawa Y, Onodera K, Kamei J.
Role of delta-opioid receptor subtypes in anxiety-related behaviors in the elevated plus-maze in rats.
Psychopharmacology 182(3):327-34. (2005)

212. Kamei J, Tamura N, Saitoh A.
Possible involvement of the spinal nitric oxide/cGMP pathway in vincristine-induced painful neuropathy in mice.
Pain. 117(1-2):112-20. (2005)

213. Chiba Y, Murata M, Ushikubo H, Yoshikawa Y, Saitoh A, Sakai H, Kamei J, Misawa M.
Effect of cigarette smoke exposure in vivo on bronchial smooth muscle contractility in vitro in rats.
Am J Respir Cell Mol Biol. 33(6):574-81. (2005)

214. Nozaki C, Saitoh A, Tamura N, Kamei J.
Antinociceptive effect of oxycodone in diabetic mice.
Eur J Pharmacol. 524(1-3):75-9. (2005)

215. Utsunomiya H, Yamakawa T, Kamei J, Kadonosono K, Tanaka S.
Anti-hyperglycemic effects of plum in a rat model of obesity and type 2 diabetes, Wistar fatty rat.
Biomed Res. 26(5):193-200. (2005)

216. Kamei J, Miyata S, Takahashi M, Saitoh A.
Involvement of delta1-opioid receptors in the spatial learning impairment in streptozotocin-induced diabetic mice.
Nihon Shinkei Seishin Yakurigaku Zasshi. 25(5):221-5. (2005)

217. Kamei J, Takahashi Y, Yoshikawa Y, Saitoh A.
Involvement of P2X receptor subtypes in ATP-induced enhancement of the cough reflex sensitivity.
Eur J Pharmacol. 528(1-3):158-61. (2005)

218. Miyata S, Hirano S, Kamei J.
Abnormal benzodiazepine receptor function in the depressive-like behavior of diabetic mice.
Pharmacol Biochem Behav. 82(4):615-20. (2005)

【総説】

1. 亀井淳三:鎮咳薬の中枢薬理
薬物・神経・行動 (Japanease Journal of Psychopharmacology) 13, 271-284 (1993)

2. Kamei, J.: Recent advances in neuropharmacology of the centrally acting antitussive drugs.
Methods and Findings in Experimental and Clinical Pharmacology 17, 193-205 (1995)

4. Kamei, J.: Role of opioidergic and serotonergic mechanisms in cough and antitussives.
Pulmonary Pharmacology 9, 349-356 (1996)

5. 亀井淳三:中枢性鎮咳薬の作用機序
日本薬理学雑誌 111, 345-355 (1998)

6. 亀井淳三:シグマ受容体リガンドの薬理作用‐鎮咳作用、抗潰瘍作用などを中心として‐
日本薬理学雑誌 114, 35-41 (1999)

7. Kamei, J., Mizoguchi, H., Narita, M. and Tseng, L.F.: Therapeutic potential of PKC inhibitors
in painful diabetic neuropathy. Expert Opinion on Investigational Drugs 10, 1653-1664 (2001)

8. Kamei, J.: -opioid receptor antagonist as a new concept for central acting antitussive drug.
Pulmonary Pharmacology & Therapeutics 15, 235-240 (2002)

9. 亀井淳三,圖子田 康,宮田茂雄:糖尿病態による中枢神経作用薬の感受性変化‐オピオイドおよびベンゾジアゼピン系薬物を中心に‐
日本神経精神薬理学会雑誌 22: 121-129 (2002)

10. 斎藤顕宜、山口和正、村沢寛泰、亀井淳三
動物モデルによる抗うつ薬の創薬 「恐怖条件付けストレスモデル」および「嗅球摘出モデル」を用いた抗うつ薬創薬のアプローチ
日本神経精神薬理学雑誌 23(2):75-82. (2003)

11. 宮田茂雄、平野祥子、亀井淳三
糖尿病は5-HT1A受容体を介した抗うつ様効果を減弱させる
日本神経精神薬理学雑誌 24(3):159-163. (2004)

【著書】

1. Kamei, J. and Kasuya, Y.:The effects of diabetes on opioid-induced antinociception. In The Pharmacology of Opioid Peptides, edited by L.F. Tseng, Harwood, Amsterdam, pp. 271-286, (1995)

2. 亀井淳三:呼吸器系用薬,薬理学(MR教育研修テキスト基礎学術2),高久史麿,粕谷 豊監修,ミクス,P104-115,1995

3. 池田康夫,亀井淳三:MRのためのQ&Aによる要点チェック 疾病と薬物治療編,ミクス,1997

4. 亀井淳三:メキシレチンの抗侵害作用機序,オピオイド−適正使用と最近の進歩−,鎮痛薬・オピオイドペプチド研究会編,ミクス,P.126-134,1997

5. 亀井淳三(分担執筆):薬物治療学,高橋隆一,南原利夫監修,ミクス,1997

6. 亀井淳三:医薬品情報業務,病院実習プレトレーニング,村田正弘,百瀬和亨監修,ミクス,P86-93,1998

7. 亀井淳三:糖尿病動物の侵害受容閾値に対するnociceptin/orphanin FQの作用,疼痛治療の現状と展望,鎮痛薬・オピオイドペプチド研究会編,ミクス,P.192-200,1998

8. 亀井淳三(分担執筆):薬理学,南原利夫総監修,重信弘毅監修,ミクス,P.101-112,1999

9. 亀井淳三:薬剤師国家試験のためのQ&Aによる要点チェック 疾病と薬物治療,薬剤師教育研究会編,ミクス,1999

10.亀井淳三(分担執筆):薬剤師国家試験のためのQ&Aによる要点チェック 薬理学,薬剤師教育研究会編,ミクス,1999

11.亀井淳三:オピオイドの基礎知識@特徴および作用メカニズム,オピオイドのすべて,鎮痛薬・オピオイドペプチド研究会編,ミクス,P.25-36,1999

12.亀井淳三:麻薬拮抗性鎮痛薬の基礎薬理−@ブプレノルフィンの薬理作用−,オピオイドの基礎と臨床,鎮痛薬・オピオイドペプチド研究会編,ミクス,P.100-105,2000

13.亀井淳三(分担編集):日常会話医療用語集第7版,池田康夫,南原利夫編,ミクス,2000

14.亀井淳三:神経因性疼痛,動物実験モデルとメカニズムA糖尿病性神経障害に伴う痛覚過敏の成因,オピオイド治療−課題と新潮流−,鎮痛薬・オピオイドペプチド研究会編,ミクス,P.195-203,2001

15.亀井淳三:MR認定試験徹底研究,‐チェックポイントと厳選問題‐,疾病と薬物治療編,エルゼビア・サイエンス ミクス,2001


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